GETTING MY LDN-27219 PHARMACOLOGICAL PROPERTIES TO WORK

A single notably intriguing compound is LDN-27219. Whilst most tTG inhibitors are designed to bind into the protein crosslinking Energetic website, LDN-27219 rather binds to the nucleotide binding pocket with the enzyme although it's in its shut-state conformation, and stabilizes that conformation to forestall crosslinking activity.78 Schneider et